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News 2015

December 31, 2015

The 2015 top ten programming languages. Source: spectrum.ieee.org         


December 30, 2015

A reading list to expand your mind (BBC). Source: bbc.co.uk          

Highlights from 2015 (BBC). Source: bbc.co.uk         

Practical artificial intelligence tools you can use today. Source: Kurzweilai.net           

Single-molecule detection of contaminants, explosives or diseases now possible. Source: Kurzweilai.net      


December 29, 2015

The top A.I. breakthroughs of 2015. Source: Kurzweilai.net      

How brain architecture relates to consciousness and abstract thoughts. Source: Kurzweilai.net           


December 26, 2015

Opinion Paper: Targeting Multiple Cyclin-Dependent Kinases (CDKs): A New Strategy for Molecular Docking Studies. Source: Current Drug Targets     


December 25, 2015

How to Learn an Algorithm. Source: Kurzweilai.net  


December 23, 2015

New genes associated with extreme longevity identified. Source: Kurzweilai.net  

A ‘garbage disposal’ drug may slow Alzheimer’s and other neurodegenerative diseases. Source: Kurzweilai.net      

Mathematical model for animal stripes. Source: www.sciencedaily.com      


December 22, 2015

How to teach machines to see. Source: Kurzweilai.net

Genetic ‘intelligence networks’ discovered in the brain. Source: Kurzweilai.net   

December 21, 2015

AI ‘alarmists’ nominated for 2015 ‘Luddite Award’. Source: Kurzweilai.net    

Magnetic nanoparticles combat biofilms, a source of chronic bacterial infections. Source: Kurzweilai.net     

Deep-learning algorithm predicts photos’ memorability at ‘near-human’ levels. Source: Kurzweilai.net      


December 18, 2015

Scientists blueprint tiny cellular 'nanomachine'. Source: www.sciencedaily.com      


December 17, 2015

And Science’s Breakthrough of the Year is... Source: news.sciencemag.org            

NuSTAR finds cosmic clumpy doughnut around black hole. Source: jpl.nasa.gov        


December 15, 2015

Importance of physical activity and aerobic exercise for healthy brain function. Source: Kurzweilai.net   


December 14, 2015

New mass spectral imaging instrument maps cells’ composition in 3-D at more than 100 times higher resolution. Source: Kurzweilai.net   

Will this DNA molecular switch replace conventional transistors? Source: Kurzweilai.net     


December 11, 2015

Musk, others commit $1 billion to non-profit AI research company to ‘benefit humanity’. Source: Kurzweilai.net     


December 10, 2015

Periodic table of protein complexes helps predict novel protein structures. Source: Kurzweilai.net   

Worm research in life extension leads scientists to discover new metric to track aging. Source: Kurzweilai.net  

When machines learn like humans. Source: Kurzweilai.net   

Germany fires up bizarre new fusion reactor. Source: news.sciencemag.org   


December 8, 2015

Parkinson’s disease researchers discover a way to reprogram the genome to produce dopamine neurons. Source: Kurzweilai.net   

Can physical activity make you learn better? Source: Kurzweilai.net   

December 7, 2015

Por que a Finlândia está mudando 'um dos melhores sistemas de educação do mundo'?. Source: bbc.com   

Python 3.5.1 is available for download. Source: python.org  

As the worm turns: research tracks how an embryo’s brain is assembled. Source: Kurzweilai.net   

'Nanobombs’ that blow up cancer cells. Source: Kurzweilai.net      

Hybrid solid-state chips and biological cells integrated at molecular level. Source: Kurzweilai.net      


December 4, 2015

Possible biochemical mechanism underlying long-term memories identified. Source: Kurzweilai.net        

First direct evidence for synaptic plasticity in fruit fly brain. Source: Kurzweilai.net    


December 1, 2015

Do fish have emotions and consciousness? Source: Kurzweilai.net     


November 25, 2015

The hunt for Albert Einstein's missing waves. Source: bbc.com     

Army ants’ ‘living’ bridges suggest collective intelligence. Source: Kurzweilai.net      


November 24, 2015

Master genetic switch for brain development discovered. Source: Kurzweilai.net     

First real-time imaging of neural activity invented. Source: Kurzweilai.net      


November 20, 2015

A sensory illusion that makes yeast cells self-destruct. Source: Kurzweilai.net    

Researchers discover signaling molecule that helps neurons find their way in the developing brain. Source: Kurzweilai.net          


November 19, 2015

Exercise may protect against neurodegenerative diseases. Source: Kurzweilai.net      


November 17, 2015

Modulating brain’s stress circuity might prevent Alzheimer’s disease. Source: Kurzweilai.net          

Allen Institute researchers decode patterns that make our brains human. Source: Kurzweilai.net    


November 16, 2015

‘Super natural killer cells’ destroy cancer in lymph nodes to halt metastasis. Source: Kurzweilai.net     

Reprogramming neurons and rewiring the brain. Source: Kurzweilai.net   


November 13, 2015

Beyond telomerase: another enzyme discovered critical to maintaining telomere length. Source: Kurzweilai.net 

Experimental drug targeting Alzheimer’s disease shows anti-aging effects. Source: Kurzweilai.net    

IBM’s Watson shown to enhance human-computer co-creativity, support biologically inspired design. Source: Kurzweilai.net   


November 9, 2015

Google open-sources its TensorFlow machine learning system. Source: Kurzweilai.net     


November 3, 2015

Engineers design enhanced magnetic protein nanoparticles to better track cells. Source: Kurzweilai.net     

Semantic Scholar uses AI to transform scientific search. Source: Kurzweilai.net          

First complete pictures of cells’ DNA-copying machinery. Source: Kurzweilai.net          


November 2, 2015

Massive supercomputer simulation models universe from near birth until today. Source: Kurzweilai.net         

Single-agent phototherapy system diagnoses and kills cancer cells. Source: Kurzweilai.net   

How to build a full-scale quantum computer in silicon. Source: Kurzweilai.net     


October 30, 2015

Long-term aerobic exercise prevents age-related brain deterioration. Source: Kurzweilai.net      


October 28, 2015

What happens in the brain when we learn. Source: Kurzweilai.net          


October 26, 2015

A drug-delivery technique to bypass the blood-brain barrier. Source: Kurzweilai.net    


October 24, 2015

A powerful new ‘tool’ for assembling biomolecules. Source: Kurzweilai.net   


October 23, 2015

Processing 3.0.1 is available for download. Source: processing.org  


October 22, 2015

Improving learning and memory in aged mice with cholesterol-binding membrane protein. Source: Kurzweilai.net     

Largest astronomical image to date contains 46 billion pixels. Source: Kurzweilai.net     


October 21, 2015

Is your thinking chaotic? There’s a model for that. Source: Kurzweilai.net     


Redesigned Structure Summary Page of Protein Data Bank. Source: www.rcsb.org/pdb

 Comment by Prof. Walter.

 The redesined structure summary page had missing information about ligand-binding affinity. Now they fixed this issue. See e-mails below.


Fwd: Missing binding affinity information in the new version of PDB
De: "Peter Rose" <peter.rose@rcsb.org> para mim - 21/10/2015 16:12

Dear Prof. Filgueira de Azevedo Jr.,


Thank you for reporting the issue. We will fix it with next Wednesday's weekly update.
However, there is a much easier way to retrieve binding affinity information using our RESTful web services.
For example, using our custom report web service, you can retrieve ligand and binding affinity information: http://www.rcsb.org/pdb/rest/customReport?pdbids=1SPT,1OHR&customReportColumns=resolution, structureId,chainId,ligandId,ligandMolecularWeight,ligandFormula,ligandName,ligandSmiles,InChIKey,Ki,Kd,EC50,IC50,deltaG,deltaH,deltaS,Ka&service=wsfile&format=csv&ssa=nTo learn more about our web services, please see the following pages:http://www.rcsb.org/pdb/software/wsreport.do
http://www.rcsb.org/pdb/software/rest.do

If you have any question, I'd be happy to do a Skype session and walk you through the details.
Best regards,

Peter

-- 
Peter Rose, Ph.D.
Site Head, RCSB Protein Data Bank West (http://www.rcsb.org)
San Diego Supercomputer Center (http://bioinformatics.sdsc.edu)
University of California, San Diego
+1-858-822-5497

http://www.rcsb.org/pdb/software/wsreport.do
---------- Forwarded message ----------

From: "Walter Filgueira de Azevedo Jr." <walter@azevedolab.net>
To: <deposit-help@mail.wwpdb.org>
Cc: 
Date: Wed, 21 Oct 2015 11:52:50 -0200
Subject: Missing binding affinity information in the new version of PDB

Dear Sir(or Madam),

 Congratulations for the new design of PDB page. It looks great. But, unfortunately a feature related to binding affinity is missing. In the previous version, the HTML code had binding information, for instance IC50. In this new version, I can't find any binding information in the site. I know I can find binding information in another database, for instance, BindingDB, but it seems to me that it is there in the PDB, since it is possible to search at advance search for structures with binding information.
Please, if you have any part of the PDB, that brings this information (IC50, Ki, Kd deltaG) send me the link, and also in which format it was stored. I have been working in the development of a program (sandres.net), in which one of the features was the download of binding information from the PDB. This information was at http://www.rcsb.org/pdb/explore/explore.do?structureId=XXX
 where XXX is the PDB access code. And it was in HTML format, so it was very useful.
 Thank you very for your time.
 Kind regards,

                    Walter.


May 5, 2015

A surprisingly simple bug afflicts computers. Source: bbc.com        

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