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Research


Editor for the Following Journals


This page brings material for the courses that I teach in post-graduate  and undergraduate courses. The material is in Portuguese except for Drug Design course. For most of the courses that I teach, I have adopted the project-based learning approach. In project-based courses, it is proposed for the students a list of potential projects to be developed during the course. These projects are focused on proteins, as the ones described in the video on the left.

Prof. Walter F. de Azevedo Jr., PhD.

Crystallization of protein in a microgravity environment (video in Portuguese). Experiments carried out on the Discovery space shuttle STS-95 on October 29, 1998.

Project-Based Learning     

The project-based learning allows the students to apply the basic knowledge of a course to develop research projects where they can exercise their creativity and become more interested in the content of a discipline. As an example, let's consider the Drug Design course, I propose a list of research projects focused on the protein targets listed below. The students choose one of the protein targets and carry out docking simulations to identify potential new inhibitors for these enzymes. The same list of enzymes is used for Bioinformatics and Machine Learning courses. In the Machine Learning course, the students are asked to develop machine learning models to predict ligand-binding affinity for a specific enzyme. In the Bioinformatics courses, the students are invited to create Python codes to analyze protein-ligand interactions, using the protein targets as study cases. For those interested in the project-based learning and project-driven learning, I have included a list of sites below.


Research Projects          

     -Acetylcholinesterase (EC 3.1.1.7)   PubMed   MOTM                   
     -Beta-Lactamase (or Cephalosporinase) (EC 3.5.2.6)   PubMed   MOTM            
     -Beta-Secretase 1 (or Memapsin 2) (EC 3.4.23.46)   PubMed   MOTM          
     -Carbonic Anhydrase II (or Carbonic Dehydratase) (EC 4.2.1.1)   PubMed   MOTM                    
     -Caspase-3 (or Apopain) (EC 3.4.22.56)   PubMed     MOTM   
     -Chorismate Synthase (EC 4.2.3.5)   PubMed   
     -Cyclin-Dependent Kinase 1 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 2 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 4 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 5 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 6 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 7 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 8 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 9 (EC 2.7.11.22)   PubMed       
     -Cyclin-Dependent Kinase 12 (EC 2.7.11.22)   PubMed      
     -Cyclin-Dependent Kinase 13 (EC 2.7.11.22)   PubMed      
     -Cyclin-Dependent Kinase 16 (EC 2.7.11.22)   PubMed       
     -Cyclooxygenase-1 and 2 (EC 1.14.99.1)   PubMed   MOTM   
     -Cytochrome P450 2C9 (EC 1.14.13.-)   PubMed   MOTM   
     -Dihydrofolate Reductase (or Tetrahydrofolate Dehydrogenase) (EC 1.5.1.3)   PubMed   MOTM   
     -Enoyl-[Acyl-Carrier-Protein] Reductase (NADH) (or Enoyl-ACP Reductase) (EC 1.3.1.9)   PubMed   
     -3-enol-pyruvoylshikimate-5-phosphate synthase (EPSP synthase) (EC 2.5.1.19)   PubMed     
     -Epidermal Growth Factor Receptor ErbB1 (EC 2.7.10.1)   PubMed   MOTM     
     -Human Immunodeficiency Virus Type 1 Integrase (EC 2.7.7.-)   PubMed   MOTM   
     -Human Immunodeficiency Virus Type 1 Protease (EC 3.4.23.16)   PubMed   MOTM   
     -Human Immunodeficiency Virus Type 1 Reverse Transcriptase (EC 2.7.7.49)   PubMed  MOTM   
     -Muscle Glycogen Phosphorylase (or Amylophosphorylase) (EC 2.4.1.1)   PubMed   MOTM   
     -Nitric-Oxide Synthase, Brain (EC 1.14.13.39)   PubMed   MOTM   
     -Neuraminidase (or Exo-Alpha-Sialidase) (EC 3.2.1.18)   PubMed   MOTM   
     -Phospholipase A(2) Group IIA (EC 3.1.1.4)   PubMed   
     -Purine Nucleoside Phophorylase (or Inosine Phosphorylase) (EC 2.4.2.1)   PubMed   
     -RAF Protein Kinases (EC 2.7.11.1)   PubMed   MOTM      
     -Serotonin Receptor   PubMed   MOTM    
     -Shikimate Kinase (EC 2.7.1.71)   PubMed   
     -Tyrosine-Protein Kinase SRC (EC 2.7.10.2)   PubMed  MOTM   
     -Zinc Fingers   PubMed  MOTM   

Links Related to Project-Based Learning   

     -ASCD          
     -Buck Institute for Education (BIE)          
     -edglossary.org           
     -George Lucas Education Foundation (Edutopia)          
     -Learn NC                   
     -Thinkful